1-Phenyl-1-cyclopentanecarboxylic acid 2-(diethylamino)ethyl ester
caramiphen
CAS: 77-22-5
Molecular Formula: C18H27NO2
1-Phenyl-1-cyclopentanecarboxylic acid 2-(diethylamino)ethyl ester - Names and Identifiers
1-Phenyl-1-cyclopentanecarboxylic acid 2-(diethylamino)ethyl ester - Physico-chemical Properties
| Molecular Formula | C18H27NO2 |
| Molar Mass | 289.41 |
| Boling Point | bp0.07 112-115° |
| Physical and Chemical Properties | Chemical liquid. Boiling point 156-158 ℃(0.93kPa),110-115 ℃(6.65 × 10-3kPa). |
| Use | Uses the product and ethane two sulfonic acid salt, that is, cough medicine cough, Cough inhibition of the role of the center. For tuberculosis, bronchitis, bronchitis, influenza caused by Cough. |
1-Phenyl-1-cyclopentanecarboxylic acid 2-(diethylamino)ethyl ester - Upstream Downstream Industry
1-Phenyl-1-cyclopentanecarboxylic acid 2-(diethylamino)ethyl ester - Uses and synthesis methods
overview
Caralmefene can inhibit the cough center, is a non-addictive antitussive, has local anesthesia and mild bronchiectasis, but has no analgesic and respiratory depression effects.
production method
It is obtained by esterification of 1-phenylcyclopentane formyl chloride and diethylamino ethanol. Add 1-phenylcyclopentane formyl chloride into a dry reaction pot, stir and cool to 10-15 ℃, add diethylamino ethanol dropwise, gradually increase the internal temperature to 110 ℃, add it within 2.5-3h, stir for 30min, heat to 115-125 ℃, react for 2-2.5h, discharge the material while hot, and leave overnight. Add 5 times the amount of water to dissolve, add 10% hydrochloric acid to pH = 6-7. Filter to remove insoluble matter. After extracting the filtrate with benzene, add activated carbon, decolorize at 70-80 ℃ for 2 hours, and filter. Add sodium carbonate to the filtrate to neutral, precipitate the oil layer, wash to neutral with a saturated solution of sodium sulfate, add anhydrous sodium sulfate to dry, filter, and obtain the base of Kemefen.
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: Pentoxyverine Impurity 2 (Pentoxyverine EP Impurity B) Visit Supplier Webpage Request for quotationCAS: 77-22-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
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Spot supply
Product Name: Pentoxyverine Impurity 2 (Pentoxyverine EP Impurity B) Visit Supplier Webpage Request for quotationCAS: 77-22-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
View History
Raw Materials for 1-Phenyl-1-cyclopentanecarboxylic acid 2-(diethylamino)ethyl ester